Lexical Definition

‎διαπονέω‎ diaponéō (dee-ap-on-eh'-o) be vexed G:V
from ‎διά‎ and a derivative of ‎πόνος‎

be grieved.

Usage: 3 forms in 3 verses
Form Translated As     In Verse(s)
διαπονούμενοι being distressed Acts.4.2
διαπονηθεὶσ Having been distressed Acts.16.18
διαπονηθήσεται shall work hard LXX.Eccl.10.9

Abbott-Smith

δια-πονέω, -ῶ [in LXX: Ec 10:9 (עצב ni.), II Mac 2:28; in Aq.: Ge 6:6, I Ki 20:3 * ;]
to work out with labour. Pass., to be worn out, sore troubled: Mk 14:4 (WH, mg.), Ac 4:2 16:18.†

Abbott-Smith References

Book Refs
Genesis 6:6
1 Samuel 20:3
Ecclesiastes 10:9
Mark 14:4
Acts 4:2 · 16:18

Liddell-Scott-Jones

διαπονέω-έω,

work out with labour, elaborate, [Refs 5th c.BC+]; cultivate, practise, δ. γράμματα [Refs 5th c.BC+]; exercise, σώματα [Refs 5th c.BC+] —middle, διαπονέωεῖσθαι ἐπιτηδεύματα, τέχνας, [Refs 5th c.BC+]:—passive, [διαπονέωουμένου ">Refs 5th c.BC+]managed, governed, [Refs 4th c.BC+]; διαπονέωηθῆναι τὴν μουσικήν to be taught it thoroughly, [Refs 1st c.AD+]veterans, [Refs 1st c.BC+]

__2 till or cultivate completely, χώραν [Refs 2nd c.BC+]:—passive, [Refs]
__3 passive, to be worn out, troubled, [NT+1st c.BC+]
__II intransitive, to work hard, δ. τῇ διανοίᾳ καὶ τῷ σώματι [Refs 5th c.BC+]: with infinitive, δ. πᾶν ἰσόρροπον ποιεῖν [Refs 5th c.BC+]: —middle, δ. τὸ πᾶσαν πίστιν λαβεῖν [Refs 5th c.BC+]; οἱ διαπονέωούμενοι the hard-working, hardy, opposed to ἄπονοι, [Refs 5th c.BC+]; to be hard-worked, of hounds, [Refs 2nd c.AD+]

LSJ Scripture Refs: Acts.4.2